Two-compartment model of radioimmunotherapy delivered through cerebrospinal fluid

A pharmacokinetic model for radioimmunotherapy delivered through cerebrospinal fluid for the treatment of leptomeningeal metastases.

UNLABELLED Radioimmunotherapy can effectively treat leptomeningeal metastases when radiolabeled antibodies are administered into the cerebrospinal fluid (CSF). We developed a pharmacokinetic model to evaluate the role of kinetic and transport parameters of radioimmunotherapy in maximizing the therapeutic ratio, the ratio of the area under the curve for the concentration of the bound antibodies ...

Empirical Validation of Cerebrospinal Fluid Pulsatility Model

Enterobius vermicularis in Cerebrospinal Fluid

Enterobius vermicularis is a nematod of large intestine in man. Extra intestinal localization of this parasite is rare. A 60 year old man was admitted to the hospital with the clinical manifestation of meningitis. In laboratory examination of cerebrospinal fluid (C.S.F), the appearance was red, Albu-min level was high and the glucose showed normal value. Haematoxylin and Eosin stained slides pr...

Cerebrospinal fluid physiology and cerebrospinal fluid drainage.

To the Editor:—We read with interest the article of Conzen et al. demonstrating a reduction of cardiac troponin I release after coronary artery bypass grafting on the beating heart when sevoflurane was compared to propofol. Most previous studies identified peak postoperative troponin I as the major endpoint. It is not clear from the article of Conzen et al. which was the peak postoperative trop...

Cerebrospinal Fluid Physiology and Cerebrospinal Fluid Drainage

To the Editor:—We read with interest the article of Conzen et al. demonstrating a reduction of cardiac troponin I release after coronary artery bypass grafting on the beating heart when sevoflurane was compared to propofol. Most previous studies identified peak postoperative troponin I as the major endpoint. It is not clear from the article of Conzen et al. which was the peak postoperative trop...